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  1. JCI - Welcome

    Jan 2, 2026 · In this issue of the JCI, Goala et al. uncovered a mechanistic link between IFN-γ–driven inflammation and disrupted neutrophil homeostasis, revealing that cytokine release syndrome (CRS) …

  2. JCI - About the Journal of Clinical Investigation

    You may submit manuscripts for consideration solely by the JCI or select the Dual-Journal Submission option to have your manuscript evaluated by the JCI and JCI Insight. Start your submission by …

  3. JCI - Welcome

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    JCI is a Gold Open Access journal and deposits all published research articles in PubMed Central, which satisfies the NIH Public Access Policy and other similar funding agency requirements.

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  6. JCI - Welcome

    Genetic and environmental influences in autism: guiding the future of tailored early detection and intervention

  7. JCI - Volume 135, Issue 1

    Jan 2, 2025 · In this issue of the JCI, Derakhshan et al. elucidate the heterogeneity of MCs in nasal polyposis and identify a transcriptional signature of TGF-β target genes expressed by the …

  8. JCI - The gut microbiome and cancer response to immune checkpoint ...

    Feb 3, 2025 · The field of the microbiome and immunotherapy has skyrocketed since 2015 when two studies demonstrated a fascinating phenomenon in mice: certain gut bacteria could enhance the …

  9. JCI - Loss of Cpt1a results in elevated glucose-fueled mitochondrial ...

    Jan 9, 2025 · J Clin Invest. 2010;120 (1):142–156. View this article via: JCI CrossRef PubMed Google Scholar Ricciardi MR, et al. Targeting the leukemia cell metabolism by the CPT1a inhibition: …

  10. JCI Insight - Frequency of dengue virus–specific T cells is related to ...

    Feb 24, 2025 · The frequency of PD-1 expression among AIM + CD4 + T cells did not show an accumulation or increase in children with a higher number of dengue cases or a significant difference …