Overcoming evasive resistance from vascular endothelial …
Jun 9, 2012 · In conclusion, sarcomas respond to increased hypoxia by expressing HIF-1α target genes that may promote resistance to antiangiogenic and other therapies. HIF-1α inhibition …
Regulatory mechanisms and potential medical applications of HNF1A …
HNF1A-AS1 is dysregulated in different cancers and exerts pro-oncogenic or tumor-suppressing effects. Simultaneously, HNF1A-AS1 modulates a wide range of the vital biological processes …
Targeting epigenetic regulators as a promising avenue to …
Jul 18, 2025 · In this review, we explore the widespread dysregulation and crosstalk of various types of epigenetic modifications, including DNA methylation, histone modifications, and non …
Improving Immunotherapy Efficacy in Soft-Tissue Sarcomas: A
Dec 3, 2021 · Adoptive cellular therapies are also of great interest in tumors with a high expression of cancer-testis antigens (CTA), such as synovial sarcomas or myxoid round cell …
The lncRNA HNF1A‐AS1 is a negative prognostic factor and …
Sep 2, 2017 · Recent studies have revealed that long noncoding RNA HNF1A-antisense 1 (HNF1A-AS1) plays an important role in the development of several human malignancy …
Regulatory mechanisms and potential medical applications of HNF1A …
Jun 15, 2022 · HNF1A-AS1 exerts its oncogenic roles through a variety of molecular mechanisms. Moreover, aberrant HNF1A-AS1 expression is associated with diverse clinical features in …
Targeted inhibition of the HNF1A/SHH axis by triptolide
We demonstrated that triptolide directly bound to HNF1A, one of the transcription factors of SHH, and inhibited HNF1A/SHH expression, ensuing in attenuation of Hedgehog signaling.
Integrated bioinformatic analysis of HNF1A in human cancers
Hepatocyte nuclear factor 1A (HNF1A) is an important transcription factor that regulates multiple biological processes. Our research focused on elucidating the expression and function of …
Inhibition of vascular endothelial growth factor A and hypoxia ...
Dec 4, 2024 · Human sarcomas with a poor response to radiation therapy (RT) and vascular endothelial growth factor A (VEGF-A) inhibition have upregulation of hypoxia inducible factor …
Targeting FGFR4 abrogates HNF1A-driven metastasis in ... - Springer
Jul 29, 2025 · In the current study, we aimed to determine whether HNF1A serves a role in promoting metastasis of PDAC, and the mechanisms by which it does so. Using in vitro and in …