A small-molecule compound named TAC has been identified that reawakens the catalytic subunit of telomerase (TERT) in somatic cells and, in doing so, stalls multiple hallmarks of natural aging without ...

Small molecule restores TERT levels, reversing hallmarks of aging A high-throughput screen of over 650,000 compounds identified a small-molecule TERT activating compound (TAC) that epigenetically ...

Pulmonary carcinoids are rare tumors of the lung with extremely different clinical courses. In many patients, they behave like benign tumors; surgical removal of the tumor leads to a complete cure.

Researchers have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical ...

Tumor agnostic efficacy and safety of erdafitinib (erda) in patients (pts) with advanced solid tumors with prespecified FGFR alterations (FGFRalt): RAGNAR primary analysis.

To identify TERT-PM and TERT-RA, tumors were profiled by the Memorial Sloan Kettering Cancer Center-Integrated Mutation Profiling of Actionable Cancer Targets targeted next-generation sequencing ...

Telomeres, posted at the edges of chromosomes, protect DNA from damage. The telomerase enzyme helps maintain the length and integrity of telomeres and acts as an aging regulator. Researchers have now ...

A new study in mice and human cells suggests that a small molecule can help reverse signs of aging by extending telomeres and modulating key genes. When you purchase through links on our site, we may ...