Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

In this study, researchers used positron emission tomography and a special tracer to study the relationship between the distribution of an important neuronal receptor (AMPA) and the occurrence and ...

Research led by SUNY Downstate Medical Center has identified a brain receptor that appears to initiate adolescent synaptic pruning, a process believed necessary for learning, but one that appears to ...

AMPA-type glutamate synaptic receptors (AMPA-Rs) mediate a wide variety of excitatory synaptic transmissions in the brain. The mechanism by which these receptors maintain a long-term synaptic efficacy ...

A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...

Neural activity in healthy brain releases glutamate which binds to synaptic receptors and activates Ca ++ influx and further signaling pathways of CAM/ERK/MAPK/CREB in neurons. CREB elevation leads in ...

Oligomeric amyloid-β (Aβ) peptide causes synaptic dysfunction, accumulates within synapses, and has been associated with synapse loss around plaques in Alzheimer’s disease (AD). However, there is a ...

Researchers are testing a new approach to repair early memory loss by protecting brain connections affected in Alzheimer’s ...

Ten years ago, three research teams published a breakthrough — the first description of the molecular mechanism for transduction in fingertip sensory Merkel cells that can transduce gentle touch, a ...

2 Department of Psychiatry, University of Toronto, Faculty of Medicine, 33 Russell Street, T-109 Toronto, ON M5S 2S1, Canada 3 Multimodal Imaging Group, Centre for Addiction & Mental Health, Toronto, ...