How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details ...

Technological advances in mass spectrometry are aiding researchers to image and characterize protein and other cellular components with increasing resolution. Using native ambient mass spectrometry ...

Native Capillary Electrophoresis–Mass Spectrometry Enables Quantitative Profiling of Endogenous Protein Complexes ...

In his lecture after winning a share of the 2002 Nobel Prize in Chemistry, John Fenn described his work as creating “wings for molecular elephants”. Fenn pioneered the use of a method called ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...

As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...

A disassembled charge-detection mass spectrometry ion trap. A disassembled charge detection mass spectrometry ion trap Credit: Gwendolyn Jarrold At the University of Oxford, Justin Benesch studies ...

A new technique based on fluorescence resonance energy transfer (FRET)-based single-molecule protein fingerprinting can identify where specific amino acids and post-translational modifications are ...

In this webinar recent applications of mass photometry are highlighted especially focusing on higher-order protein assemblies as present in our blood. In particular, the ability of mass photometry to ...

What are some important lessons you have learned in your career, and are there any important people that have helped you along the way? When I started my career in biotechnology, my boss was Rich ...

New study reveals how mass spectrometry can be used to determine the mechanisms used by molecular glues to stick to their targets. Molecular glues are a continually expanding area of medicinal ...