Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...

One of the hallmarks of Alzheimer's disease is the clumping of proteins called Tau, which form tangled fibrils in the brain.

Macromolecular crowding is a central concept in understanding how proteins function in the dense and heterogeneous intracellular environment. In crowded cellular conditions, high concentrations of ...

A team of international researchers led by scientists at City of Hope ®, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National ...

MIT chemists used NMR spectroscopy to reveal the disordered “fuzzy coat” surrounding Tau protein fibrils, offering new ...

A novel protein cage system can control and visualize orientational changes in aromatic side chains upon ligand binding. By inducing coordinated molecular changes, this approach enables precise ...

The cell cytoskeleton is modulated by motor proteins, known as dyneins, that generate force and movement on microtubules to control a wealth of biological processes, including motility, cell division, ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

The question has been lingering for years in medical science circles. Since 2020, when the artificial intelligence (AI) model AlphaFold made it possible to predict protein structures, would the ...

A research team reports that advances in protein design—especially when combined with artificial intelligence—are rapidly ...