Low complexity (LC) head domains 92 and 108 residues in length are, respectively, required for assembly of neurofilament light (NFL) and desmin intermediate filaments (IFs). As studied in isolation, ...
How intermediate filaments polymerize and assemble in vivo is largely unknown. Now, a study reveals that this assembly is regulated by sumoylation of the cytoplasmic intermediate filament protein B-1A ...
Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2418624122 Scientists have uncovered new details about cellular filaments that play a critical role in wound healing, ...
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