Complete disruption of the CXCR4 chemokine receptor gene is embryologically lethal in mice, 11, 12 impeding direct study of CXCR4-mediated tumor progression and metastasis. Current approaches to study ...
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FDA Grants Orphan Drug Designation to Cellenkos' CK0804 Treg Therapy for Treatment of Myelofibrosis
Treg therapeutic designed to preferentially traffic towards its ligand CXCL12 over expressed in the bone marrow and spleen in myelofibrosis. -- CK0804 engages with antigen presenting cells within ...
Human immunodeficiency virus (HIV) infection is a viral infection that causes acquired immunodeficiency syndrome (AIDS) by gradually destroying certain leukocytes. When HIV enters the human body, it ...
The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...
Dan G. Duda, DMD, PhD, of the Edwin L. Steele Laboratories for Tumor Biology and Department of Radiation Oncology at Massachusetts General Hospital, is the corresponding author of a paper published in ...
The FDA approved mavorixafor (Xolremdi) capsules as the first therapy specifically for WHIM syndrome, a rare primary immunodeficiency and chronic neutropenic disorder, X4 Pharmaceuticals announced on ...
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